Gas Chromatography–Mass Spectrometry Testing

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Gas chromatography-mass spectrometry is a means of analyzing samples to identify individual substances using the features of gas-liquid chromatography as well as mass spectrometry.

What Is Gas Chromatography-Mass Spectrometry?

 autosampler of gas chromatography

Gas Chromatography-Mass Spectrometry is a method that labs use to detect trace amounts of substances in one sample. Lab facilities that perform testing on urine samples use it to uncover anything that contributes to the substance in question.

Not only does it check for specific materials within the sample, but it also is specific and precisely reveals what it discovered. So, if you’ve been having a little too much fun lately, not only will it test positive but they’ll know precisely what kind of fun you’ve been having.

How Does It Work

hand at work and start Gas Chromatography Analyzer in laboratory

Let’s talk about science. The gas chromatograph is composed of a heated inlet port and oven. It also contains a fused silica column that the technician will coat with a unique material they call the stationary phase.

Once this is complete, the process is ready to begin. It generally consists of four steps:

  1. Preparing The Sample: To equip the sample, the technician will dissolve or dilute the sample in a solvent and inject it into the inlet port.
  2. Vaporizing: The sample turns from liquid to gas through vaporization.
  3. Separating: The gas then travels through a column. Depending on the gas’s chemistry, the substances will react in different ways with the column stationary phase. Their reaction causes them to move faster or slower through the column, and they separate.
  4. Detecting: Once separate, the compounds exit the column and move to the mass spectrometer.

The results will appear on a line graph. They represent the separate substances with a peak. The amount of peaks that appear shows how many compounds are in the sample.

History

Quality Control Lab vials on autosampler medicine chromatograph

In 1952, gas chromatography-mass spectrometry testing was developed by Martin and James. However, at that time these machines could only be used in laboratories.

Making computers smaller and cheaper has helped make this test simpler and reduced the time it takes for analysis of a sample. Under the supervision of Robert E. Finnigan, a company called Electronic Associates, Incorporated, which supplied analog computers, started developing a quadrupole mass spectrometer that was controlled by a computer in 1964.

With the help of Mike Uthe, by 1966, Electronic Associates had sold more than 500 gas-analyzers. The Finnigan Instrument Corporation established in 1967, and Perdue and Stanford University got the first prototype of the quadruple gas chromatography-mass spectrometry instrument.

Finnigan Instrument Corporation became the leader, worldwide, in gas chromatography-mass spectrometry systems and ultimately changed its name to Finnigan Corporation.

The high-speed gas chromatography-mass spectrometry instruments were able to analyze fire accelerants in less than a minute and a half in 1966, while the original gas chromatography-mass spectrometry instruments took 16 minutes or more.

Computerized gas chromatography-mass spectrometry units, which use quadruple technology, became one of the leading tools for analyzing organic materials by the 2000s.

This method also became necessary for chemical research by the 2000s. They are now, to an extensive degree, used to monitor water, air and soil environmentally. They also use them for the production and discovery of medicine, and to regulate food safety and agriculture.

The Uses Of Gas Chromatography-Mass Spectrometry

man using a gas chromatograph

There are many different ways to use gas chromatography-mass spectrometry. It’s sort of a genius invention that has contributed towards a more significant cause on so many levels since its creation.

Gas chromatography-mass spectrometry can be used to investigate fires and explosives, for environmental analysis, to detect drugs and to identify substances of an unknown origin. It can identify elements in materials that used to be considered too disintegrated to locate.

Gas chromatography-mass spectrometry can also detect substances on a human being or in luggage as they pass through airport security.

Because gas chromatography-mass spectrometry testing performs a specific test, it has been considered to be a paragon of excellence when it comes to identifying forensic substances. A test that is specific will show the presence of a particular matter in a specific sample.

A test that is not specific will not show the presence of a specific matter. Instead, it will show the category in which that the matter fits into.  The problem with a test that is not specific is that, statistically, it may imply that a particular material is present.

However, this can be misleading, causing a false positive identification.

Outsmarting The Machines

Winking businessman

As humans, we’d like to think that we’re smarter than most machines. And indeed we are. At least in this instance. While specific chemists work to uncover recreational substances in urine screenings, there are some who work to keep them hidden.

Synthetic urine is formulated in a lab to match the natural chemicals our body secretes precisely. It has the exact creatines levels, ph balance, and uric acid.

Quick Fix synthetic urine is guaranteed to pass or your money back. And by the way, it has an excellent reputation for being undetectable for all types of urine testing.

Is synthetic urine not your forte? That’s okay because Quick Fix also offers a fast acting detox drink. Follow the directions carefully and drink plenty of water and you’ll pass your test with no problems.

To avoid false identification in non-specific tests, and to protect one’s privacy, when using gas chromatography-mass spectrometry, the production of lab grade urine has become necessary.

Spectrum Labs urine passes gas chromatography-mass spectrometry screening tests. It is tested, using this method, prior to being packaged. Therefore, they offer a 200% guarantee that their lab grade synthetic urine will pass gas chromatography-mass spectrometry testing.

It comes in discreet packaging and appears under an undercover name. So, you’re secret is safe with us. We offer single packages of urine for one time screenings. Or if you know you’re susceptible to random tests, buy in bulk to ensure they don’t catch you off guard.

Don’t waste money on other brands and products that cause you to test positive. Get your Quick Fix Synthetic Urine today before you get the dreaded plastic cup.

Resources

https://www.sciencedirect.com/topics/earth-and-planetary-sciences/gas-chromatography-mass-spectrometry

https://www.ncbi.nlm.nih.gov/pubmed/8075776

https://www.nmslabs.com/tests/8098U

 

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